If Nancy Grace were focused on good news, she’d call it a “bombshell” – What Professor Richard Sharpe, Principal Investigator at the Independent Medical Research Center’s Center for Reproductive Health in Britain calls a “majestically scientific” study concluding that BPA is safe…
“Why is the media ignoring the study?,” Asks Forbes blogger Trevor Butterworth. Perhaps it is because bad news has more reader/viewer appeal than good news. That why stories about priests who run away with nuns get more notice than the retirements of good vicars after unblemished careers of service…
Canners will find a lot to be cheered about in this study. In light of its findings, one wonders why EPA, one of study’s sponsors, went ahead with its proposal to mandate testing of sites where BPA is released…
See the blog here.
Read an abstract of the study (below) or purchase the full study (here) from Toxicological Sciences where it first appeared online on June 24th
Abstract
By virtue of its binding to steroid hormone receptors, BPA (unconjugated monomer) is hypothesized to be estrogenic when present in sufficient quantities in the body, raising concerns that widespread exposure to BPA may impact human health. To better understand the internal exposure of adult humans to BPA and the relationship between the serum and urinary pharmacokinetics of BPA, a clinical exposure study was conducted. Blood and urine samples were collected ∼hourly over a 24-hour period from twenty adult volunteers who ingested 100% of one of three specified meals comprising standard grocery store food items for breakfast, lunch, and dinner. The volunteers’ average consumption of BPA, estimated from the urinary excretion of total BPA (TOTBPA=conjugated BPA + BPA), was 0.27 μg/kg body weight (range, 0.03-0.86), 21% greater than the 95th percentile of aggregate exposure in the adult U.S. population. A serum time course of TOTBPA was observable only in individuals with exposures 1.3-3.9 times higher than the 95th percentile of aggregate U.S. exposure. TOTBPA urine concentration Tmax was 2.75 hours (range, 0.75-5.75 hours) post meal, lagging the serum concentration Tmax by ∼1 hour. Serum TOTBPA area under the curve per unit BPA exposure was between 21.5 and 79.0 nM•hr•kg/μg TOTBPA. Serum TOTBPA concentrations ranged from ≤ limit of detection (LOD, 1.3 nM) to 5.7 nM and were, on average, 42 times lower than urine concentrations. During these high dietary exposures, TOTBPA concentrations in serum were below the LOD for 86% of the 320 samples collected and BPA concentrations were determined to be ≤ LOD.
Study clearing BPA: Ignored because it won’t sell newspapers?
If Nancy Grace were focused on good news, she’d call it a “bombshell” – What Professor Richard Sharpe, Principal Investigator at the Independent Medical Research Center’s Center for Reproductive Health in Britain calls a “majestically scientific” study concluding that BPA is safe…
“Why is the media ignoring the study?,” Asks Forbes blogger Trevor Butterworth. Perhaps it is because bad news has more reader/viewer appeal than good news. That why stories about priests who run away with nuns get more notice than the retirements of good vicars after unblemished careers of service…
Canners will find a lot to be cheered about in this study. In light of its findings, one wonders why EPA, one of study’s sponsors, went ahead with its proposal to mandate testing of sites where BPA is released…
See the blog here.
Read an abstract of the study (below) or purchase the full study (here) from Toxicological Sciences where it first appeared online on June 24th
Abstract
By virtue of its binding to steroid hormone receptors, BPA (unconjugated monomer) is hypothesized to be estrogenic when present in sufficient quantities in the body, raising concerns that widespread exposure to BPA may impact human health. To better understand the internal exposure of adult humans to BPA and the relationship between the serum and urinary pharmacokinetics of BPA, a clinical exposure study was conducted. Blood and urine samples were collected ∼hourly over a 24-hour period from twenty adult volunteers who ingested 100% of one of three specified meals comprising standard grocery store food items for breakfast, lunch, and dinner. The volunteers’ average consumption of BPA, estimated from the urinary excretion of total BPA (TOTBPA=conjugated BPA + BPA), was 0.27 μg/kg body weight (range, 0.03-0.86), 21% greater than the 95th percentile of aggregate exposure in the adult U.S. population. A serum time course of TOTBPA was observable only in individuals with exposures 1.3-3.9 times higher than the 95th percentile of aggregate U.S. exposure. TOTBPA urine concentration Tmax was 2.75 hours (range, 0.75-5.75 hours) post meal, lagging the serum concentration Tmax by ∼1 hour. Serum TOTBPA area under the curve per unit BPA exposure was between 21.5 and 79.0 nM•hr•kg/μg TOTBPA. Serum TOTBPA concentrations ranged from ≤ limit of detection (LOD, 1.3 nM) to 5.7 nM and were, on average, 42 times lower than urine concentrations. During these high dietary exposures, TOTBPA concentrations in serum were below the LOD for 86% of the 320 samples collected and BPA concentrations were determined to be ≤ LOD.